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Which Remedies For Baldness Work?
Which hair loss treatments work?
For every hair loss treatment, I divide it into two categories: “drugs” and “natural.” Both of these hair loss treatments are said to work to a certain extent. These drugs (creams and pills) have undergone various clinical trials, but the downside is that they are sometimes prone to unwanted side effects. Natural remedies for hair loss often have no attached clinical trials, just word of mouth recommendations, but usually have fewer reported side effects (at least fewer unwanted ones). If you’re not sure which type to try, you can try both (but get your doctor’s advice before doing so).
Allopathic treatments for hair loss
Before I start any allopathic treatment for hair loss, I must explain the current scientific thinking behind the causes of hair loss so that it is easier to understand the mechanism and effectiveness of the medicine.
Men convert excess testosterone into a more potent form called DHT through the enzyme 5a reductase. DHT is very active on hair follicle receptors, easily locking them up and restricting blood flow to the hair. This causes the hair to become thinner and miniaturized, resulting in a “peach fuzz” appearance. Levels of this enzyme are apparently higher in the scalp of men prone to male pattern baldness.[1]
However, women have excess aromatase, which converts testosterone into an active estrogen called estradiol. The theory is that as women go through menopause, their natural estrogen levels decrease, allowing testosterone to be converted to DHT, making them more prone to postmenopausal hair loss. However, this doesn’t explain why postmenopausal men experience hair loss as they age and testosterone levels decline.[1]
Well, that’s the theory, so now let’s look at each hair loss treatment in turn and determine its effectiveness and availability as of July 2006. Here is a list of each hair loss treatment:
Rogaine (Minodo)
Propecia (finasteride)
Rogain
Mechanism – unclear. Seems to turn on potassium availability in hair.
Effectiveness – average hair growth of 18.5% per square centimeter after 48 weeks. 1 to 3 months after drug discontinuation, hair condition returns to pre-treatment level.
SIDE EFFECTS – Dizziness has been reported. Local irritation, itching, dryness, and erythema may occur with topical minoxidil, most likely due to the alcohol and propylene glycol vehicle formulation.[2]
Availability – at the counter.
Cost – $10 to $15 per bottle (one month).
Propecia
Mechanism of Action – Inhibits the enzyme 5a reductase responsible for DHT production.
Effectiveness – A third study of 326 men with mild to moderate forehead hair loss found that after 1 year, men treated with finasteride had a statistically significant increase in the amount of hair on the forehead scalp. About 50% of the men who received the treatment and 30% of the men who received the placebo reported an improvement in the appearance of their hair. Elderly men taking 5 mg of finasteride reported no hair regrowth.
Side Effects – Loss of libido, erectile dysfunction, or decreased ejaculate volume was reported in less than 2% of patients, compared with placebo, the actual incidence was between 0.5% and 1%.[2]
Availability – Prescription only. A general release is now available.
Cost – $69.95 for 3 months
Natural Remedies for Hair Loss
Most natural remedies for hair loss also work by blocking DHT, either by inhibiting the enzyme or blocking hair follicle receptors, or by feeding nutrients to DHT-blocked hair follicle receptors. The “DHT alone causes hair loss” theory also has another explanation. Some believe that too much active estrogen-like substance, along with too much DHT, is the culprit for prostate cancer and hair loss, and not enough free testosterone in the body.[3]
That sounds contradictory to the allopathic argument, and it’s the same for estrogen. Some naturopathic experts say it’s all about blocking the hair follicle’s receptors. It is these protein receptors that attract nutrients to the hair. Both DHT and estrogen-like pollutants block receptors.[3] Apparently, certain fat-eating bacteria produce estrogen-like substances[4], and excess aromatase (which converts testosterone to estrogen) is present in the fat cells of obese and balding men. Aging, high-fat diets, and lack of exercise can produce too much estrogen and too little testosterone. Even with normal testosterone levels, active estrogen levels can still be too high.[3] Although this doesn’t explain why women with high estrogen levels don’t develop male pattern baldness.
Here is a list of each hair loss treatment and nutrition:
Beta-Sitosterol (from herb: Saw Palmettool)
Chrysin (from herb: Passiflora)
Vitamin D
Vitamin B12
Biotin (Vitamin B7)
Iron and L-Lysine (for women)
Folligen (copper peptide)
soybeans
Rooibos tea
β-Sitosterol
Mechanism – Blocks DHT from the androgen receptor site found on hair follicles.
Effectiveness – Not tested. Reviews from people on health forums have been mixed.
Side Effects – None, but a side effect of the herb Saw Palmitol may be male breast enlargement.[2]
Availability – at the counter.
Cost – $7.95 for 90 Capsules of 400 mg.
Chrysin
Mechanism of Action – Increases free testosterone by inhibiting the conversion to estradiol.
Effectiveness – Shown to be effective in blocking aromatase in a dish, but not in the body. Not sure if it helps hair loss.[5] There are no proven treatments for hair loss.
Side effects – none.
Availability – at the counter.
Cost – MRM, Chrysin 500, 30 capsules. $14.99.
Vitamin D
Mechanism of Action – Binds to many vitamin D receptors in the scalp and hair follicles.
Effectiveness – Shown to significantly stimulate hair follicle growth in “nude mice”.[6]
Side Effects – None, unless taking more than 50 micrograms per day.
Availability – at the counter.
Cost – $4.99 for 400iu (10 micrograms) for 60 capsules.
Vitamin B12
Mechanism – Deficiency causes hair loss.[7]
Effectiveness – 40% of Americans lack. If taken, it is not proven to treat hair loss.[8]
Side Effects – None, unless taking more than 100 micrograms per day.
Availability – at the counter.
Cost – 1000 mcg, $7.99 for a tablet.
Biotin (Vitamin B7)
Mechanism – Increases blood flow to hair follicles.[9]
Effectiveness – It can promote hair growth in high doses, though not an effective drug for hair loss.
Side effects – none.
Availability – at the counter.
Cost – $2.99 for a 300 mcg tablet.
Iron and L-Lysine (for women)
Mechanism – Deficiencies of these two nutrients have been linked to female hair loss.[10] Interacts with zinc and copper.[11]
Effectiveness – Proven to be effective against hair loss in women with hair loss.[10]
Side Effects – None, unless taking more than 250 mg (iron) per day.
Availability – at the counter.
Cost – $7.29 for 100 Tablets
FOLLIGEN (copper peptide)
Mechanism of Action – The most potent blocker of the production of both 5a reductases.[12]
Effectiveness – Low copper and zinc enzyme levels caused hair loss in mice.[13] A topical copper peptide solution created near-perfect hair rejuvenation in 6 months for a woman who had just started to have 10% hair.[14] There are no studies on Folligen itself for treating hair loss, but some women have reported success on forums.
Side effects – none.
Availability – at the counter.
Cost – $21.95 for 2 oz tube. 2 months.
soybeans
Mechanism – Stimulates the production of good inactive estrogen. Blocks the receptor site for active estrogen and inhibits 5a reductase.[3]
Effectiveness – Demonstrated inhibition of the enzyme 5a reductase.[15]
Side effects – none.
Availability – at the counter. A food substance, not a drug for hair loss.
cost- ?
Rooibos tea
Mechanism – unclear.
EFFECTIVENESS – In a 10% lotion called herbasol, 89% of people experienced increased hair growth. 45% noticed an increase in hair growth. 78% reported no further hair loss.[2]
Side effects – none.
Availability – at the counter. A food substance, other than as described above, is not a drug for the treatment of hair loss.
cost- ?
I personally recommend trying Beta Sistosterol in combination with a strong multivitamin and mineral supplement as a hair loss remedy.
—————————————————- ————————–
[1] Did scientists accidentally discover the answer to hair loss?
http://www.emaxhealth.com/65/6131.html
[2] Treat hair loss.
[http://www.hairlosstalk.com/download/sawaya1.pdf]
[3] become younger and slimmer
[http://www.growyoungandslim.com/articles/Mens_Health_102a.pdf]
[4] health loss education
http://www.stuff4beauty.com/page/hairlosseducation.htm
[5] Chrysin: is it a potent aromatase inhibitor?
http://www.vrp.com/art/1208.asp
[6] Vitamin D3 analogs stimulate hair growth in nude mice.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12399436&query_hl=41
[7] Diet and Nutrition – Vitamin B12.
http://www.internethealthlibrary.com/DietandNutrition/VitaminB12.htm
[8] Do you need B-12?
http://thyroid.about.com/cs/newsinfo/l/blb12anemia.htm?terms=vitamin+B12+and+Tufts+
[9] Biotin and Hair Growth
http://www.add-hair.com/Biotin-hair-loss.htm
[10] Nutritional factors and hair loss.
http://www.blackwell-synergy.com/links/doi/10.1046/j.1365-2230.2002.01076.x/abs/
[11] Interactions of iron, zinc and copper in animals and humans
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2700243&dopt=Abstract
[12] follicle hormone
http://www.folligen.com/
[13] Age-related increased cochlear hair cell loss in mice deficient in copper/zinc superoxide dismutase
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10466888&dopt=Abstract
[14] Did scientists accidentally discover the answer to hair loss?
http://www.emaxhealth.com/65/6131.html
[15] Regulation of Soybean Isoflavones on Androgen Levels in Rats
http://www.leaonline.com/doi/abs/10.1207/S15327914NC422_9;jsessionid=nFFp1FovOhX-OhcS3V?cookieSet=1&journalCode=nc
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